報告人：Robert Knowles

主持人🚶🏻‍➡️：儲玲玲 研究員

時間：2024年11月19日（星期二）9:30

地點：復合材料創新協同大樓第二報告廳

報告人介紹：Professor Robert Knowles received a BS in chemistry from the College of William and Mary in 2003. He went on to receive his PhD in synthetic organic chemistry from Caltech in 2008 for his work on natural product synthesis in the labs of Dave MacMillan. Following his doctoral work, Rob moved to Eric Jacobsen’s lab at Harvard University as a NIH postdoctoral fellow, where his work focused on asymmetric catalysis and new reaction development. Rob joined the Department of Chemistry at Princeton University in the summer of 2011, where his group’s work has focused primarily on the applications of proton-coupled electron transfer (PCET) in organic synthesis. In 2017, he was promoted to Professor of Chemistry in Princeton University. Robert received the Brown Science Foundation Investigator Award (2024), ACS E.J. Corey Award (2023), ACS Arthur C. Cope Scholar Award (2018), Mitsui Catalysis Science Award of Encouragement (2018), E. Bright Wilson Prize (2018), Novartis Early Career Award in Organic Chemistry (2017), Camille Dreyfus Teacher-Scholar Award (2017), Grammaticakis-Neumann Prize (2017), Amgen Young Investigator Award (2016), Eli Lilly Grantee Award (2016), and the Alfred P. Sloan Foundation Research Fellow (2014).

報告摘要：The applications of free radical intermediates in organic synthesis have expanded significantly in recent years. However, the development of catalytic strategies that enable control of enantioselectivity in radical reactions remains challenging. In this lecture, I will describe two recently reported methods for enantioselective hydroamination that make use of attractive non-covalent associations between free radicals and chiral organocatalysts as a basis for stereocontrol. Mechanistic and computational efforts to elucidate the precise radical-molecule interactions responsible for asymmetric induction will be presented.